MyBioSource.com's Nephrin (Y1210) antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, and Western Blot. The Nephrin (Y1210) antibody was generated using CNF, Nephrin, nephrosis 1, nephrin, and NPHS1 nephrin as the antigen and it reacts with Human, and Mouse.
Description
This gene encodes a member of the immunoglobulin family of
cell adhesion molecules that functions in the glomerular filtration
barrier in the kidney. The gene is primarily expressed in renal
tissues, and the protein is a type-1 transmembrane protein found at
the slit diaphragm of glomerular podocytes. The slit diaphragm is
thought to function as an ultrafilter to exclude albumin and other
plasma macromolecules in the formation of urine. Mutations in this
gene result in Finnish-type congenital nephrosis 1, characterized
by severe proteinuria and loss of the slit diaphragm and foot
processes